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Prevention and Hygiene: Consume adequate quantities of salt and water as part of the normal diet symptoms 7 days past ovulation order nootropil 800 mg overnight delivery. No improvement/Deterioration: If recovery is not rapid (within 1-2 hours with oral fluids chi royal treatment purchase nootropil 800mg without prescription, within 15-30 minutes with normal saline) symptoms vitamin b12 deficiency purchase 800mg nootropil overnight delivery, return for reevaluation medicine misuse definition purchase 800 mg nootropil overnight delivery. Follow-up Actions Consultation Criteria: If recover is not rapid (within 1-2 hours with oral fluids, within 15-30 minutes with normal saline). Heat exhaustion may develop over several days and is a manifestation of strain on the cardiovascular system. It occurs when the demands for blood flow (to the skin for temperature control through convection and sweating, to the muscles for work, and other vital organs) exceed the cardiac output. Risk Factors: Dehydrated and sodium-deficient members are at risk after strenuous physical activity in the heat. Subjective: Symptoms Profound fatigue, thirst, nausea/vomiting, tingling of the lips, shortness of breath, orthostatic dizziness, headache, and syncope Focused History: What have you had to eat and drink in the last 48 hoursfi Assessment: Differential Diagnosis heat stroke, simple dehydration, febrile illness Plan: Treatment 1. Patient Education General: Maintain adequate fluid and water intake and work/rest cycles in heat. However, they all need at least 24 hours of rest and re-hydration under first echelon or unit level medical supervision to reverse water-electrolyte depletion. Prevention and Hygiene: Acclimatize gradually with adequate water and dietary salt. A single episode of heat exhaustion does not imply a predisposition to heat injury and no continuing follow up or profile evaluation is required. Consultation Criteria: Repeated episodes of heat exhaustion require a temporary profile against heat exposure, evacuation and referral for a thorough evaluation. The difference between heat exhaustion and heat stroke is usually impossible to determine. Soldiers who do not respond dramatically to rest and fluid/electrolyte repletion should be observed for 24 hours for delayed complications of heat stroke. If heat stroke is suspected and body temperature is elevated, start cooling immediately! Risk Factors: A history of previous heat stroke, poor physical conditioning, dehydration, high work loads in a hot environment, illness with fever, medications that interfere with sweating or contribute to dehydration such as caffeine, alcohol and diuretics. Subjective: Symptoms Dizziness, exhaustion, weakness, nausea, possible involuntary urination, confusion, delirium and other mental status changes. If they have consumed several gallons of fluid in the past 2 hours consider hyponatremiawater intoxication. A patient with mental status changes should be treated as a heat stroke patient until it is proven otherwise. Objective: Signs Using Basic Tools: Inspection: Sudden collapse and unconsciousness; diminished or absent sweating with hot, red skin; markedly elevated rectal temperature to 106-110°F (not universal); convulsions; seizures; diminished urination. Auscultation: Elevated blood pressure; rapid, deep respirations dropping off to shallow and irregular respirations. Palpation: Diminished or absent sweating with hot, red skin; rapid, thready pulse. Assessment: Differential Diagnosis infection (particularly meningococcemia and P. Field expedient baths, which will keep the water cool, can be constructed by digging plastic-lined, shaded pits. Discontinue active cooling when the rectal temperature reaches 101°F in order to avoid overcooling. Constantly monitor the patient’s body temperature and alternate heating and cooling until the temperature stabilizes. Continue monitoring the patient’s temperature every 10 minutes for the next 48 hours. Patient Education General: Avoid heat exposure until clinical recovery and a thorough medical evaluation are complete. Recovery is primarily a function of the magnitude and duration of the temperature elevation. Activity: Patients should receive profiles restricting heat exposure (a permanent profile may be issued later) until clinical recovery is complete and their heat tolerance is evaluated. Prevention and Hygiene: Avoid heat exposure for several weeks until the body can regulate heat correctly again. No improvement/Deterioration: Evacuate for additional testing and treatment with continued cooling en route. Follow-up Actions Reevaluation: Hypotensive patients who do not respond to saline may benefit from carefully titrated dopamine. Evacuation/Consultation Criteria: All heat stroke patients need mandatory evacuation and referral. Evaluation of the potential complications of heat stroke (encephalopathy, coagulopathy, hepatic injury, renal failure and rhabdomyolysis) requires laboratory tests not available in the basic or advanced management tools. Any individual who suddenly becomes a casualty without being wounded, or is suffering a greater degree of incapacitation than is compatible with his injury should be considered a possible chemical victim. It is unlikely that a chemical agent would produce only a single casualty under field conditions, and a chemical attack should be considered with any sudden increase in numbers of unexplained causalities. Subjective: Symptoms Eyes, nose and throat: Eye pain, dim vision, photophobia, nasal congestion, hoarseness. Blood Agents High concentrations of blood agents such as cyanide exert their effect rapidly, causing unconsciousness and death in a matter of minutes. However, if the patient is still alive after the cloud has passed (more than 5 minutes after presumed exposure), he will probably recover spontaneously. Objective: Signs Using Basic Tools: Violent convulsions; increased deep respirations followed by cessation of respiration within one minute; slowing of the heart rate until death. Assessment: Diagnosis based on clinical signs and symptoms, environment and probability Plan: Treatment Mask self and mask patient. Blister Agents Blister agents such as phosgene, mustard gas or Lewisite attack exposed skin and mucous membranes. They penetrate clothing and force troops to wear full protective equipment, degrading fighting efficiency. The mask protects against eye and lung damage but provides only limited protection against systemic effects. No drug is available for the prevention of the effects on the skin and mucous membranes. Phosgene penetrates garments and rubber easier than other chemical agents and produces a rapid onset of severe and prolonged effects. When mixed with other chemicals, the rapid skin damage caused by phosgene will make the skin more susceptible to the second agent. If an unmasked victim were exposed to phosgene before donning his mask, the pain caused by the agent will prompt him to unmask again. Subjective: Symptoms Burns and blisters, itching, pain, conjunctivitis, coughing, shortness of breath, vomiting and diarrhea. Objective: Signs Using Basic Tools: General: Shock after large exposure to Lewisite, resulting from protein and plasma leakage from capillaries and subsequent hemoconcentration and hypotension. Skin: Reddened and extremely pruritic; progresses in 4-24 hours to blistering, which may be severe depending on agent and exposure. Apart from mucous membranes, the face, neck and skin-on-skin areas (armpits, genitalia, webs of the digits, etc. Respiratory tract: Swelling impeding the airway, tissue sloughing, hyperactive airways, tracheobronchial stenosis, pulmonary edema. Assessment: Diagnosis based on clinical signs and symptoms, environment and probability Plan: Treatment Mask self. Burns: Treat burns similarly to second-degree thermal burns (clean, prevent infection). Larger blisters should be unroofed and the area irrigated 4 times daily with soapy water and covered liberally with Silvadene Cream or suitable substitute. Treat mild exposure as conjuctivitis More severe injuries require daily irrigation, topical antibiotics and a topical mydriatic. Apply Vaseline to lid edges to prevent adherence, reduce scar formation and allow for a path for infection to drain if present. Topical steroid may be helpful in the first 48 hrs but of no benefit after that period.

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Postoperative pain is minimal since phenol has a local anesthetic action and is an antiseptic medications 230 800 mg nootropil free shipping. However medicine 1975 800 mg nootropil fast delivery, the effect of 20% ferric chloride after phenol chemical matricectomy4 results in a signifcant reduction in oozing from the operation site treatment 4 anti-aging order nootropil 800 mg overnight delivery. An elliptical wedge-shaped tissue excision is carried out from the lateral wall of the toe and limited to treatment 24 seven buy nootropil 800 mg free shipping its distal lateral portion around the distal phalanx to a distance of about 4 mm from the nail (Figure 17. The defect is closed with 5-0 monoflament sutures that are removed after 14–21 days. Pincer Nails the dystrophic condition called pincer nails is characterized by transverse overcurvature that increases along the longitudinal axis of the nail and reaches its greatest extent at the distal part, leading to trumpet nails. This condition may be so painful that even the use of a bedsheet may become unbearable in adulthood. There are several different variants of pincer nails, both hereditary (Figures 17. Of interest, epidermolysis bullosa simplex (Dowling-Meara type) may be associated with pincer nail abnormality, with a slight thickening, in both fnger and toenails. Pincer nail deformity has also been reported as a manifestation of Clouston syndrome. Acquired pincer nails are not symmetrical, though fngernail involvement may be extensive and appears to be fairly symmetrical. Acquired pincer nails may be due to a number of different dermatoses, of which psoriasis is the most frequent. Tumors of the nail apparatus such as exostosis and implantation cyst may lead to pincer nails, a condition reversible after the treatment of cause. Tinea ungium due to Trichophyton rubrum, affecting equally the great toenail and thumb nail, has been shown to be responsible for pincer nails. Acquired pincer nail deformity in infants with Kawasaki disease may affect all digits of the hands (Figure 17. Given the absence of pain, the nails were left undisturbed and the overcurvature spontaneously resolved as the nails grew out. Pediatric Ingrown Toenails 249 Congenital Malalignment of the Hallux Congenital malalignment of the big toenail may present with gross nail deformation, greenish-gray discoloration, thickening, and oyster shell-like appearance (Figure 17. The obliquely positioned nail usually has sharply downward-bent lateral margins, often digging into the lateral nail fold and distal nail bed (Figure 17. There is no attachment to the nail bed; therefore, counterpressure to the forces acting on the tip of the toe during gait is lacking, allowing the tip and pulp tissue to be dislocated dorsally to form a distal nail wall. The lack of attachment to the nail bed epithelium can readily be shown by placing a blunt-tipped probe under the nail. The ridged skin of the pulp of the toe is constantly dislocated under the free end of the nail obscuring the hyponychium. About 50% of patients experience spontaneous improvement leading to an almost normal-looking yet still malaligned nail with a good nail bed attachment before the age of 10 years. The existence of a ligamentous structure corresponding to a dorsal expansion of the lateral ligament of the distal interphalangeal joint appears to be connected with the nail matrix. Its physical properties may change with the passage of time, and this therefore explains spontaneous cures. If the deviation is marked and the nail buried in the soft tissues, the surgical rotation of the misdirected matrix associated with the simple section of the dorsal expansion of the lateral ligament is essential to prevent permanent nail dystrophy (Figure 17. In addition, proximal granulation tissue, infammatory subungual exudate, and onycholysis are very often observed and play an important role in the maintenance of retronychia. In early cases, a conservative treatment with an adhesive technique is a valid option. Grasp Reflex Multiple Ingrowing Fingernails There is a new clinical entity of ingrowing fngernails of infants being associated with the grasp refex, inducing paronychia (Figure 17. A grasp refex may be elicited by the stimulation of the palm of the hand by frm pressure to produce fexion of the fngers. Congenital hypertrophy of the lateral nail folds of the hallux: Clinical features and follow-up of seven cases. Congenital malalignment of the big toenail as a cause of ingrowing toenail in infancy. The treatment of choice for ingrown nail has long been surgical due to the misunderstanding of its pathophysiology. Definition Ingrown nail is defned as a nail plate digging into the periungual soft tissue, which is the lateral nail folds, the proximal nail fold, the nail bed, or distal nail fold. Frequency Ingrown nails are one of the most frequent nail disorders of children and young adults, severely interfering with daily activities and sports. Age and Gender Ingrown nails are observed at any age, from neonates to very old age. There is a slight to marked male predominance in the most common, adolescent type of lateral ingrowing. To the contrary, retronychia is, at least in our experience, slightly more frequent in girls and young women. Cutting the nail too short, diagonally, round, or pointed can leave behind hidden spicules or offending lateral nail edges and partial nail loss. These irregular nail edges pierce the epidermis of the surrounding soft tissue causing pain, infammation, and granulation tissue due to a chronic foreign-body reaction elicited by the nail digging into the dermis. Ill-ftting footwear compressing the distal nail bed with its too-short nail further compounds the problem. Improper nail cutting by patients, parents, caregivers, doctors Normal cut V cut Round cut Short cut 2. However, these upward pressure forces from the ground on partial or entire nail loss caused by improper nail cutting, nail trauma, or nail avulsion gives rise to the development of a distal nail fold and distal–lateral bulging as there is no pulp support, often with resulting bone changes such as the development of a distal dorsal exophytic growth or—in the very young—an upward deformation of the distal phalanx (Figure 18. Hypertrophic distal bulging disturbs nail regrowth, leading to ingrown nails and onychogryphosis4–6 (Figure 18. The secondary cause of ingrown nail is improper footwear, which can occur with shoes that have inadequate toe-box room (too small or big) and socks that apply external pressure at the sides, top, or front. Other factors include overcurved or pincer nails, hallux valgus, and other foot deformations, inward rotation of the big toe, gait abnormalities, age-associated changes, lack of walking and exercise, obesity, systemic illness, hyperhidrosis, diabetes, onychomycosis, drug side effects, neoplastic conditions of the nail apparatus, and participation in sports activities. Clinical Features of Ingrown Nail in Children Ingrown nails occur at every age (Figure 18. They are a signifcant problem in pediatric patients and, in particular, adolescents and youth (school children and young adults, ages 6–18). Among our study population, although ingrown nails were seen in all age groups, over one-third (35. Newborns and infants tend to go barefoot, have thin nail plates, light body weight, and low physical and walking activity. Young adults have higher physical activity levels, such as sports, dancing, and afterschool activities. The pathologic stages of ingrown nails are classifed as follows14: the frst or early infammatory stage is characterized by erythema, slight edema, and pain upon pressure; the second by pus discharge; and the third by granulation tissue formation with chronic infammation, hypertrophy, and/or induration of the nail fold (Figure 18. Ingrown nails mainly occur at distal–lateral or lateral nail folds,1–3 but may involve each nail fold: distal nail fold (distal nail embedding, distal or anterior ingrown nail) and proximal nail fold (retronychia15 or posterior ingrown nail). In children, ingrown nails occur mainly on the lateral nail folds of the toes (92. Symptoms include tenderness, limited movement, discomfort, or worsening of pain from tight footwear and sensitivity to pressure of any kind, even the weight of bed sheets or comforters. Children may hide their ingrown nail from their parents, even though the condition can cause signifcant pain. Parents should carefully observe their children’s actions to detect ingrown nail problems. Natural Course If left untreated, most ingrown toenails worsen with time and the overgrowth of the infamed nail folds, including distally, may occur. Since it is the nail plate that grows into the nail fold, the latter has to be protected against the former by pulling it away (taping), by inserting a buffer between them (packing and gutter), or by combining these methods. They offer quick reduction of pain, infammation and granulation tissue, and nail fold protection with promising results. Anchor taping and acrylic affxed gutter splint are effective on their own or in combination. Foot care with soaking, proper nail trimming and footwear, antibiotics, and steroids can be considered in combination.

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Diet: Additional calcium if suspect stress fracture Medications: All medications may produce allergic reactions treatment 21 hydroxylase deficiency nootropil 800 mg mastercard. Prevention and Hygiene: Proper training may prevent development of stress fractures symptoms of strep buy nootropil 800 mg amex. Follow-up Actions Return evaluation: If pain persists medicine lodge kansas purchase nootropil 800 mg overnight delivery, reconsider diagnosis and consult specialist or evacuate patient xerostomia medications that cause purchase nootropil 800 mg with mastercard. Evacuation/Consultation Criteria: Evacuate cases of joint infection, fracture or suspected fracture, and aseptic necrosis. Also, evacuate any unstable patient or any team member unable to complete the mission without burdening the team. Narrow the diagnostic possibilities based on the mechanism of injury (acute/trauma vs. Chronic knee pain occurs without a specific initiating event, but may be preceded by a long history of minor complaints. Pain from injuries to the collateral ligaments or menisci are referred to the side of injury. In addition to local causes, knee pain may result from referred pain such as femoral shaft stress fracture. Risk Factors: Malformations or variations in anatomic structures may predispose to overuse injuries. Subjective: Symptoms Constitutional: Limp or inability to walk; fever (suggests an acute single joint septic arthritis caused by gonorrhea until proven otherwise). Palpation: Compare knees throughout exam for temperature differences (increased warmth suggests infection or prepatellar bursitis). Perform passive range of motion with hand on knee feeling for abnormal limitations in motion, clicking or popping (cartilage, ligament or meniscal injury). Assess meniscal integrity (tears cause joint line tenderness, effusion, and positive McMurray sign [pain with passive extension of knee while externally rotated]). If tender, bend the knee medially and laterally at 0 and 30° of flexion (increased opening suggests tear). If patient unable to walk, use crutches, cane and/or splint (may be field expedient). Gonococcal arthritis is the most likely cause of infection in an otherwise intact knee without a history of trauma. Then, continue therapy for least 7 days with cefixime 400mg bid or ciprofloxacin 500mg bid. Aspirate pus/fluid and consider injecting anesthetic to enable member to walk out in combat conditions (see Procedure: Joint Aspiration). Injecting steroids is contraindicated-steroids may allow infection to rapidly worsen. Patient Education General: Unless truly catastrophic, most knee injuries will resolve through conservative treatment, rehabilitation and/or laparoscopic surgery. Activity: Depending on severity of injury, gradually advance range of motion, then add strength program with weight bearing as tolerated. Review sexual history and provide appropriate treatment for sexual contacts of patients with gonococcal arthritis. Evacuation/Consultation Criteria: Evacuate those unable to complete the mission or keep up with the team. Consult Orthopedics for cases of severe knee pain or recurrent, persistent or occult injuries. Risk factors are previous injury, parachute landings, or walking in rough terrain. Subjective: Symptoms Acute pain (immediate onset to a few hours) is usually due to trauma, or more rarely infection or severe infiammation. Chronic pain is usually due to old recurrent trauma causing degenerative joint disease. Constitutional: Acute constitutional symptoms of infection could include fever, malaise, chills, and nausea. Other joints that may be involved include the midfoot (Lisranc’s joint), metatarsals (especially the fifth), the tarsal navicular, and fibular head. Palpation: Palpate for a sensation of warmth (suggesting infection or infiammation) and edema (suggesting trauma). Palpate the posterior aspect of the medial and lateral malleolus, palpate any area of tenderness, but especially, the base of the fifth metatarsal Using Advanced Tools: X-rays (when if available), Lab: Gram stain of aspirated joint fiuid if infection or gout is suspected. Ottawa Ankle Rules Always obtain x-rays to rule out fracture when any of the following are present: 1. Unable to walk immediately after injury and when evaluated Assessment: Differential Diagnosis the history and physical will almost always lead to an accurate diagnosis. Joint infections are very rare without pre-existing trauma and the patient will not want to move their ankle at all. Sprain, fracture/dislocation, infection, infiammatory joint disease such as gout or pseudogout, degenerative joint disease, other arthritis. If unable to walk or bear weight, and even with suspected fracture, ambulating with improvised crutches or cane is preferred over a litter patient from an operational perspective. If infection is suspected, and MedEvac is unavailable, treat with antibiotic regimen (see Knee Pain section) 4. No Improvement/Deterioration: If infected joint or compound fracture, concern for systemic infection/sepsis. The theory is to use the ankle as rapidly as possible while protecting from reinjury. Under normal conditions, this would take 3-6 weeks depending on the severity of the sprain and number of previous sprains. Providing ankle support such as with an Aircast or slide-on brace with laces may help speed return to activity. Obviously, if under operational constraints, ankle sprains are not life threatening and the injured person may use the ankle to the best of their ability as tolerated. Evacuation/Consultation Criteria: Suspected fractures should have x-rays as soon as practical. Infected joints and compound fractures wreak much havoc quickly, making the earliest available MedEvac most appropriate for definitive care. Most inflammation of the penis is related to the presence of foreskin and may be an early sign of diabetes mellitus. Skin infections in the genital area are similar to cellulitis in other parts of the body, in that they present with pain and redness and are usually caused by staphylococcal or streptococcal organisms. Skin inflammation/infection in this region can lead to urethral stricture or perirectal abscess. This later infection can involve multiple organisms, including gram-negative rods, that can lead to life threatening necrotizing fasciitis (Fournier’s gangrene), particularly in the severely injured or diabetic patient. With severe inflammation of the penis, patients may have difficulty voiding or may experience symptoms of septicemia: fever, fatigue and shock. Phimosis patients will be unable to retract their foreskin, and in severe cases, the glans and urethral meatus cannot be seen. In paraphimosis, the foreskin is trapped behind the glans with a doughnut-shaped swelling of the foreskin between a tight constricting band in the penile skin and the glans. Both conditions are a result of scar tissue forming on the foreskin at the most distal aspect of the foreskin when the foreskin is extended. Balanitis: Inflammation of the glans penis and foreskin occurs primarily in the uncircumcised male but is rare in the circumcised male. The glans will look wet, red and may have multiple small red bumps and a whitish material on the surface consistent with yeast. There are a number of non-infectious causes of a wet, red patch of skin on the glans penis. When in doubt treat for infection, 3-77 3-78 and refer for biopsy if the condition does not resolve. Thrombosed Penile Vein and Sclerosing Lymphangitis: the shaft of the penis just under the skin and on the surface of the erectile bodies contains numerous large veins that can develop clots. Fournier’s Gangrene: this condition is life threatening and is most likely to occur in the severely injured patient with poor circulation or diabetes. It presents as a rapidly spreading skin inflammation with development of necrotic/purplish tissue.

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In this circumstance the usual practice is to treatment upper respiratory infection order nootropil 800mg visa infuse low dose heparinized saline into the cannulas and reassess frequently treatment magazine order 800mg nootropil free shipping. The cannulae are removed and the vessels simply ligated (or occasionally repaired) medications made from animals generic nootropil 800 mg with mastercard. When removing a venous cannula medicine queen mary buy nootropil 800mg on-line, air can enter the venous blood through the side holes if the patient is breathing spontaneously. This is prevented by a Valsalva maneuver on the ventilator, or by short-term pharmacological paralysis when removing the venous cannula. The definition of irreversible heart or lung damage depends on the patient and the resources of the institution. In each case, a reasonable deadline for organ recovery or replacement should be set early in the course. Fixed pulmonary hypertension leading to right ventricular failure in a patient with respiratory failure has been considered an indication of futility in the past. These patients may require months of support, so should be managed in facilities equipped for providing months of support. Management of air leaks Chest tube placement is frequently accompanied by bleeding complications and need for thoracotomy, so a conservative approach is often taken to pneumothoraces. In some cases, it may be necessary to manage the airway by continuous positive airway pressure at 10, 5, or even 0 cm/H2O for hours or days leading to total atelectasis. If the cardiac output and hemoglobin concentration are adequate, arterial saturation as low as 75% is safe and well tolerated. Continuous hemofiltration can and should be added to the circuit if pharmacologic diuresis is inadequate. The hourly fluid balance goal should be set (typically 100 to 300 cc/hr for adults) and maintained until normal extracellular fluid volume is reached (no systemic edema, within 5% of “dry” weight). Although normal renal function can usually be maintained, the life threatening condition is respiratory failure. There is a tendency to drift into positive fluid balance, more sedation, increasing ventilator settings which should be carefully avoided. This condition has the characteristics of chronic irreversible obstructive lung disease; however, this condition almost always reverts to normal within 1-6 weeks. However, we do not know what the survival is in similar patients managed with conventional care in the centers reporting to the registry. Clinical research in acute fatal illness: lessons from extracorporeal membrane oxygenation. Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. The executive committee identified a working least 2 h) group of experts in emergency medicine, critical care, and Creatinine increase 0. The primary authors of each or 70 mmol/L) section (listed first in Appendix E1) initially drafted the Tissue perfusion variables proposed recommendations and associated grading of evidence. Hyperlactatemia (2 mmol/L) After meeting in March 2004, the executive committee Decreased capillary refill or mottling developed an initial consensus on the final content, recommendations, and grading of evidence. Diagnostic criteria for sepsis, adapted from Levy 16 consensus was reached with all authors. With kind permission of Because of the breadth of this topic, the authors have Springer Science and Business Media. A recent study defined severe sepsis as “infection” infection accompanied by evidence of a systemic response called 3 and “new-onset organ dysfunction,” using consensus the systemic infiammatory response syndrome. Systemic 14 definitions, and validated the coding scheme with prospective infiammatory response syndrome is defined as the presence of 2 clinical data. The study estimated that there are 751,000 cases or more of the following: (1) temperature greater than 38°C of severe sepsis per year in the United States. Organ dysfunction can be defined as activation of monocytes, macrophages, and neutrophils that acute lung injury; coagulation abnormalities; thrombocytopenia; interact with endothelial cells through numerous pathogen altered mental status; renal, liver, or cardiac failure; or 21 recognition receptors. Septic shock is defined mobilization of plasma substances as a result of this cellular as the presence of sepsis and refractory hypotension, ie, systolic activation and endothelial disruption. Activation of the complement and coagulation Bacteremia is the presence of viable bacteria in the blood and 23-27 cascades further amplifies this elaborate chain of events. The initial response to an infecting organism is a systemic response, with release of infiammatory mediators and activation of the coagulation cascade. Microvascular injury, thrombosis, and diffuse endothelial disruption follow, resulting in imbalance between oxygen delivery and oxygen consumption. After oxygen is extracted at the tissue level, the oxygen use resulting from microcirculatory dysfunction and 25,35,36 remainder returns to the venous circulation. First, although sepsis is commonly systemic oxygen delivery and the percentage of oxygen extracted characterized as hyperdynamic, some patients may present in (normally 25%) by the tissues is the systemic oxygen the early stages with a decreased preload because of concomitant 37 consumption. The balance between systemic oxygen delivery left ventricular dysfunction and hypovolemia. After fiuid and consumption is refiected by the mixed venous hemoglobin resuscitation to normalize filling pressures, compensatory oxygen saturation (SvO2). Global tissue hypoxia results when mechanisms of ventricular dilatation and tachycardia permit a there is an inability of systemic oxygen delivery to meet the transition to a hyperdynamic state or high cardiac output. This “distributive shock” refers to a state of either Cardiovascular Insufficiency and Global Tissue Hypoxia systemic or regional hypoperfusion as a result of derangements One of the most important events leading to morbidity and in blood fiow distribution and loss of vasoregulatory control to mortality in patients with sepsis is the development of the vascular beds. Global tissue hypoxia (or oxygen deprivation), a result of effects of infiammatory mediators, can be the 30 which can occur before the development of hypotension, predominant hemodynamic feature in up to 15% of patients results in further endothelial activation and generalized presenting with severe sepsis/septic shock and may be especially 25,31-34 38,39 infiammation. Initial measurement of hemoglobin and oxygen delivery, the bioenergetics of cellular oxygen extraction hematocrit levels will commonly reveal hemoconcentration 36,56 and use or respiration may also be impaired. These derangements further contribute to level less than 30% is a specific criterion for transfusion in the cardiovascular insufficiency and may occur independent of resuscitation protocols to be discussed below, repeated hemodynamic parameters, such as arterial blood pressure. Other systemic infiammatory response (pulmonary artery) and central venous lactate levels. Leukocytosis, neutrophilia, and protein, interleukin 6, procalcitonin, protein C) have been 32 Annals of Emergency Medicine Volume fifi, fifi. In general, presence of these markers has been inclusion of patients who either recovered from their initial associated with increasing morbidity and mortality. Blood cultures will be hypoxia within the first 6 hours of disease presentation positive in about 50% of patients with severe sepsis/septic (Figure 4). The recommended practice is to culture more than 20 optimizing preload, afterload, oxygen content, and mL of blood divided evenly into aerobic and anaerobic contractility to achieve a balance between tissue oxygen 82 bottles. The total volume appears to be more pressure, mean arterial pressure, and ScvO 84,85 2 important than timing or use of multiple sites. For suspected indwelling line 30%, (4) inotrope therapy, and (5) intubation, sedation, and infection, the catheter should be removed as soon as possible paralysis as necessary to achieve a ScvO2 of greater than 70% as and the tip cultured. For hypotension not responding to volume resuscitation, vasopressors used to maintain mean arterial pressure 65 mm Hg. E pine ph rine –1 m in and at 0 –0 at 0 –0 I ncre as e s aus e s tach yd ys r yth m ias, 1 m g m L kg m in kg m in le ukocytos is; incre as e s m yocard ialoxy e n cons um ption and lactate prod uction D obutam ine –2 kg S om e I ncre as e aus e s tach yd ys r yth m ias, m in and in occas ionalg as trointe s tinal 2 m g m L lare d is tre s s, incre as e s d os ag e s m yocard ialoxy e n cons um ption, ypote ns ion in volum e d e ple the d patie nt; as le s s pe riph e ral vas ocons triction th an d opam ine. N itrog lyce rin m in S m ooth m us cle S li t d e cre as e aus e s e ad ach e, d izzine s s, 1 m g m L re laxation of tach ycard ia, orth os tatic coronaryand ypote ns ion, ype rs e ns itivity s ys the m ic re action ve s s e ls 0 o e f f e ct; mild e f f e ct; mod e rate e f f e ct; marke d e f f e ct; ve rymarke d e f f e ct. This Vasoactive Agents period represented only 6 to 8 hours of a 13-day average Vasopressors should be administered when hypotension is hospital stay. In the presence of have been raised, such as the use of blood products, monitoring 93 hypotension, organ perfusion cannot be maintained with of central venous oxygen saturation, and inotrope use. Existing evidence does not clearly support the components of early goal-directed therapy are all recommended 103 superiority of one vasopressor over another. A potential therapy should be used as the first means of resuscitation, with survival benefit has been suggested with the use of simultaneous prioritization of appropriate empirical 105 norepinephrine compared with dopamine. The specific both an and adrenergic agonist up to 10 g/kg/minute procedures to institute early goal-directed therapy are discussed and is an alternative in a patient who is in need of a below. Phenylephrine, a Hemodynamic Monitoring pure adrenergic agonist, at a dosage of 40 to 200 Optimal titration of fiuids and vasoactive therapy is g/minute is an alternative vasopressor for patients with performed more objectively with invasive monitoring. Central significant tachycardia because of its ability to induce refiex 106,107 venous access allows measurement of central pressure and bradycardia. When administered in a relatively small, patient, and rapidity with which therapies can be modified, it physiologic dosage, 0.

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