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Salads that are highly sensitive to erectile dysfunction causes high blood pressure buy sildalis 120mg fast delivery oxidation (such as those including butterhead and iceberg lettuces) are? Because the atmospheric composition at steady state does not depend on the initial gas mixture within the pack (Fishman et al impotence following prostate surgery discount sildalis 120mg. These detrimental atmospheric conditions result in a physiological disorder and exudation by the carrot tissue impotence pump medicare purchase sildalis 120 mg overnight delivery. This sap provides microorganisms impotence 22 year old discount sildalis 120mg without prescription, including lactic acid bacteria, with a good growth substrate (Carlin et al. Special products requiring an O2-deprived atmosphere, such as sliced apples or prepeeled fresh potatoes, may be packed in high barrier? More recently, Belgian and Dutch processors have manufactured fresh fruit salads with syrup stabilized with sorbate (to prevent yeast growth), ascorbic acid (as an antibrowning agent), and calcium chloride (to reduce texture breakdown). The stabilization of fresh fruit salads packed without any liquid (syrup or fruit juice) requires only a few ppm of sorbate, because only the? Dry fruit chunks must be packed in almost airtight containers and under anoxia in order to prevent browning. When the fruit chunks are immersed, the sorbate concentration must be much higher, from 350 ppm (sorbic acid) when distributed between 0 and 4?C to 1000 ppm when stored at ambient temperature (20?C). Vegetable Mixes Stir fry and other preparations to be served with meat are increasingly popular in Europe. These products, already developed in the United States, are being adapted to the European market. In one such machine, the stump of a broad-leaved plant is seized by a claw that spins, thus? The green extremity of the outer leaves is torn off by static knives placed at an optimal distance and angle from the rotation axis. A study has also been conducted in which the salad is trimmed with a water jet guided by computerized image analysis. Chlorine-Free Fresh-cut Commodities As previously mentioned, the use of chlorine for disinfecting in the food industry is controversial and forbidden for organic food. Gamma irradia tion and accelerated electrons are effective on shredded root vegetables but result in a dramatic texture breakdown when applied to green salads. The detrimental effect of tem perature abuse may also be buffered by the packaging of fresh-cut bags or punnets in polystyrene boxes instead of cartons. Microorganisms in Foods 2: Sampling for Microbiological Analysis: Principles and Speci? During 1995 alone, major outbreak investigation linked infections with Salmonella serotype Stanley to alfalfa sprouts, Salmonella Hartford to unpasteurized orange juice, Shigella spp. More recently in the United States, the Center for Science in the Public Interest ranked fresh produce the fourth highest cause of all food illness since 1990 (Figure 4. In a related study, labeled multi-ingredient foods,? 14 outbreaks over the 10-year period (1990?2000) were attributed to bagged salads as well as salad bars and processed items not devoted exclusively to produce items (Scruton, 2000). The importance of fresh produce as a vehicle for pathogen transmission and those speci? Media attention to fresh and fresh-cut produce has heightened consumer aware ness of produce safety. In 1998, a Fresh Trends survey, conducted by the Packer magazine, found that 60% of consumers are more concerned today than they were a year ago about Salmonella and other bacteria in produce. Processors of fresh-cut produce have long understood their responsibility for providing a microbiologically safe, high-quality product to the consumer. Within two years of establishing an industry association of processors and suppliers in 1987, a sanitation task force was commissioned to develop model sanitary guidelines for the membership. The culmination of this work was a publication entitled Recommended Sanitary Guidelines for the Produce Processing Industry? that was released in 1992. Despite the many technological and educational advances within the fresh-cut industry in its short history, the challenge remains how to best ensure product safety. The purpose of this chapter is to review some control measures for safety and provide a preventative strategy that has proven most advantageous for minimizing food safety hazards. However, because microbiological safety is the major issue of concern in the fresh cut industry, it will be the focus of this chapter. One category concerns the factors or conditions contaminating fresh produce with indigenous pathogens during cultivation or at harvest. They include poor agronomic practices, use of contaminated water for crop irrigation or mixing chem ical sprays, application of improperly composted manure as fertilizer, and lack of training among? Poor sanitary control during postharvest handling activities is another mechanism for pathogen contamination to fresh produce. DeRoever (1999) reported that two large cases of salmonellosis occurred in 1991 and 1993 due to fresh tomato consumption. The suspect tomatoes were epidemiologically linked to a single tomato packinghouse. Although the exact contaminating point was never pinpointed, possible sources included improperly cleaned bins, buckets, and trucks used for transporting tomatoes from the? A second category of microbiological risk is the cutting or slicing operation in the fresh-cut plant. Internal tissue of fresh produce is normally protected from micro biological invasion by waxy outer skins and peels. However, cutting circumvents this physical barrier, allowing juices to leak from inner tissues onto the surfaces of fruits and vegetables. Together with an increase in exposed surface area, large microbiological populations, including potentially higher human pathogen levels, develop on cut produce items (Brackett, 1987; Garg et al. Key microbiological risks of fresh cut produce have been determined (Hurst, 1995; Fain, 1996; Zagory and Hurst, 1996) and include the following: there is no kill step (such as cooking) in the process to eliminate potential human pathogens; several pathogens. Growers, packers, and shippers of fresh produce have recently been provided a guide on how to minimize microbiological safety hazards during agricultural operations. Fresh-cut processors must have a comprehensive sanitation program, encompassing the facility, equipment, and personnel, as part of their quality assurance system. Microbiological testing is performed on a given number of samples collected from a production run, or lot, of product. When employing a sampling scheme to test for the presence of micro organisms, samples must be drawn in such a manner that the microbiological quality determined by the results is an accurate representation of the microbiological char acter of the lot. Instead, cells aggregate to form a conta gious distribution (Jarvis, 1989), a type of nonhomogenous distribution. The problem of using attribute sampling (based on the binomial distribution) in looking for patho gens in fresh-cut products is that when the defective level p. It is a graph of the probability of detecting at least one defective sample (pathogen positive) for various sample sizes when the level of the defective units is 0. On the other hand, a probability approaching one is shown when the sample size approaches 5000 at a 0. Thus, if close to 100% inspection must be employed to detect low levels of pathogens in a fresh-cut product, clearly, sampling is an inadequate means of assuring safety in products leaving the processing plant. It aims to identify possible problems before they occur and establish control measures at stages in production that are critical to product safety. Hurdle technology uses a combination of suboptimal growth conditions in which each factor alone is insuf? It offers systematic control by covering all aspects of production and handling from raw materials to consumer preparation. The result was frustration and overwork among personnel who were respon sible for monitoring and documenting these areas. For example, scarred cutting boards on a lettuce trim line may have shown to be a niche for microbiological pathogens based on equipment audits, if careful sanitation does not exert control over this area. Army Natick Research and Development Laboratories and National Aeronautics and Space Administration to develop safe food for astronauts in the early 1960s. Pillsbury found that the only way to give 100% assurance that space foods were free of microbiological pathogens was to test all products. Finished product testing was impractical, because most of the product was used up during the destructive nature of the test procedures.

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In Taiwan erectile dysfunction over the counter medication buy 120 mg sildalis with amex, groundwater from artesian wells completed in black shales impotence remedies buy cheap sildalis 120mg online, muds and fine sands are contaminated with arsenic impotence depression buy 120mg sildalis fast delivery. The presence of arsenic in surfaces and groundwater in Latin America is associated with tertiary and quaternary volcanism in the Andes Mountains erectile dysfunction family doctor discount sildalis 120 mg without prescription. Himalayas has formed the extensive alluvial plain and delta through which the Ganges, Brahmaputra and Meghna rivers flow and which form aquifers in India and Bangladesh. Anthropogenic contamination of arsenic is due to human activities includes mining and processing of ores and manufacturing using arsenic-bearing sulfides. Biogenic sources of arsenic contamination include plants, animals and 10. Geothermal/vol canic activities Pesticides Geogenic Weathering of Seed treatment rocks and minerals Cattle dip Agricultural Fertilizers Arsenic Anthropogenic Timber treatment Tannery Industrial Electroplating Paints/chemical s Sewage Others Mining Plants Smelting Biogenic Animals/ microorganism s Figure 1. Human Blood <1 ppb Urine <100 ppb Nail <1 ppm Hair <1 ppm Soil: Arsenic is present in soil at levels ranging from 0. Drinking water: the safe level of arsenic in drinking water is still confusing (5, 7, 10, 25 or 50 ppb). Skin manifestations of arsenicosis are found in some Bangladeshi patients where their drinking water levels are below 50 ppb 12. The main problem of implementing 10 ppb in developing countries, like Bangladesh, is the absence of sensitive method for the estimation of arsenic. With the exception of some kinds of seafood, most foods contain low levels of arsenic, normally less than 0. However, rice and vegetables in Bangladesh as well as India are contaminated with high concentration of arsenic. The daily intake of arsenic by the people of different countries is reported for comparison (Figure 1. Spanish showed the highest consumption of arsenic that is followed by Japanese, Indian and French. High consumption of arsenic by Spanish or Japanese is due to high intake of seafood whereas by Indian or Bangladeshi is due to consumption of arsenic contaminated water. Human body: In arsenic non-endemic areas, the level of arsenic in human blood is <1 ppb, urine <100 ppb, nails? It is rather surprising that arsenic concentration, after entering into blood, remains very low. However, arsenic reduces the erythrocyte glutathione level indicating that while it stays in blood, it produces oxidative stress in erythrocytes. The mean reduced glutathione level in red blood cell of arsenic affected patient was 55. The muscles, bones, kidneys and lungs have the highest absolute amounts of arsenic, but skin and excretory/storage organs, such as nail and hair, have the highest concentrations. The numbers of people affected in Asia are more than the rest of the world (Ravenscroft et al. In Latin America, 14 out of 20 countries are affected with high concentration of arsenic in drinking water with total exposed people of about 14 million (Bundschuh et al. The countries having large number of arsenic exposed people and cases of arsenicosis are described below. About 95% of total population is using groundwater for drinking and cooking purposes. People of urban areas are using water of deep aquifer whereas hand pumped tube wells are used by rural people. There are more than 8,000 villages (total number of villages within the country: 87,319) where 80% of all hand pump tube wells are contaminated. About 36 million people are consuming arsenic contaminated drinking water (>10 ppb) of hand pump tube wells (Chakraborti et al. This data is based on 52,202 water samples throughout the country analyzed by flow injection hydride generation atomic absorption spectrometry. Estimation of total arsenic by atomic absorption is more reliable than kit method. Multiple Cluster Indication Survey of 2009 conducted a survey in 15,000 households across Bangladesh and showed 7. Sixty out of total 64 districts of Bangladesh are affected by arsenic contaminated drinking water. Area wise distribution of arsenic contaminated drinking water is clearly shown only in Bangladesh. High levels of arsenic in groundwater occur in the districts of Chandpur, Comilla, Noakhali, Munshiganj, Brahmanbaria, Faridpur, Madaripur, Gopalganj, Shariatpur, and Satkhira. Irrigation of cultivated land with arsenic contaminated water has polluted the 16. In reality, the number will be 2-3 times more which is due to poor statistical data. The capital city Dhaka is supplied by tap water which is not contaminated but the people (about 15 million) living within the city are consuming foodstuffs which are supplied from some of the arsenic endemic areas. A study conducted at Matlab, Bangladesh (an arsenic endemic area) shows that there were 504 confirmed cases of non-malignant skin lesion of arsenicosis among the total population of 166,934 (>4 years of age). A cross-sectional study in another arsenic endemic area in Bangladesh shows that there were 714 cases of non-malignant skin lesion among 11,438 subjects (Argos et al. Illness Males Females Combined Fatal cancer/year 3,809 2,718 6,528 Non-fatal cancer/year 1,071 1,024 2,095 Total number of cancer fatalities accumulated over 50 years 190,450 135,900 326,400 Arsenicosis Hyperpigmentation 654,718 316,511 971,230 Keratosis 277,759 74,473 352,233 Cough 21,823 68,887 90,712 Breathlessness 93,247 176,874 270,122 Glucosuria 67,887 63,551 131,439 Hypertension 94,396 88,366 182,762 Total arsenicosis cases in each year 1,209,830 788,662 1,998,498 (Koundouri, 2005; Maddison et al. It is rare where the patient is suffering from keratosis without melanosis or leucomelanosis. There is dose-response relationship between inorganic arsenic exposure and risk of hypertension (Rahman et al. The states of West Bengal, Bihar, Jharkhand, Uttar Pradesh, Assam, and Manipur are reported to be contaminated with high concentration of arsenic in drinking water. West Bengal Out of 19 districts, 9 districts of West Bengal are severely affected by arsenic contaminated drinking water. Badly affected districts are Malda, Murshidabad, Nadia, North-24-Parganas, South-24-Parganas, Bardhaman, Howrah, and Hoogly. About 26 million people of West Bengal are exposed to high concentration of arsenic (Chakraborti et al. On the basis of estimating arsenic level of 140,150 hand pump tube wells using atomic absorption spectrometer, about 50. Screening of 86,000 people show that 8,500 people were suffering from arsenicosis (9. The same research group reported that about 300,000 cases of arsenicosis with symptoms of non-malignant skin lesion are present in West Bengal (Chakraborti et al. In total, 7,218 out of 27,061 hand pump tube wells were tested which had arsenic concentration of. Out of 38 districts, 16 districts are severely affected by arsenic contaminated drinking water. Among them the badly affected districts are Bhojpur, Buxar, Vaishali, Bhagalpur, Samastipur, Khagaria, Katihar, Chapra, Munger and Darbhanga. Jharkhand Only 320 villages were screened in December 2003 and 30% of the hand pump tube wells had arsenic concentration >10 ppb. Only three districts (Ballia, Gazipur & Varanasi) out of 70 districts were screened. About 45% of the hand pump tube wells are contaminated with arsenic (>10 ppb; Ahamed et al. In Chandigarh and adjacent areas, high concentration of arsenic (>500 ppb) is present not only in hand pump tube wells but also in surface water like ponds and canals. There is 6-fold increased risk of stillbirth following exposure to high 20. No association was found between arsenic exposure and spontaneous abortion or overall infant mortality. Women had lower risks than men of developing skin lesions and showed little evidence of respiratory effects (shortness of breath at night, morning cough in smokers and shortness of breath in nonsmokers; von Ehrenstein et al. The Chinese govern ment in 1994 declared arsenicosis as an endemic disease throughout the nation and conducted a massive screening program to sample wells in about 12 per cent of the counties. Because of the large size of China, it will take several decades to complete the screening of million of wells to determine the spatial occurrence and magnitude of arsenic contamination throughout the country. The 2 total area at risk is around 580,000 km (about 4 times the size of Bangladesh).

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Intrathecal infusion systems for long-term management of chronic non-cancer pain: An update of assessment of evidence erectile dysfunction and age purchase 120mg sildalis with visa. Otherwise erectile dysfunction pump amazon purchase sildalis 120mg without a prescription, of various identifiable sources of chronic spinal pain an algorithmic approach should include diagnostic in (8 erectile dysfunction watermelon effective 120 mg sildalis,2155) erectile dysfunction treatment brisbane purchase 120 mg sildalis with amex. However, this may not time, lumbar discography time suffers from significant be applicable in each and every patient. In contrast, there is of the described algorithmic approach is to provide a good evidence to support facet joint nerve blocks in the disciplined approach to the use of spinal interventional diagnosis of lumbar facet joint pain and sacroiliac joint techniques in managing spinal pain. Furthermore, with illustrated the prevalence of lumbar facet joint pain in space constraints, comprehensive initial evaluations 15% to 45% of patients and false-positive rates of 27% and all the findings are not provided. Appropriate history, physical examination, and Furthermore, among all the diagnostic approaches in medical decision-making are essential to the provision the lumbosacral spine, medial branch blocks have the of appropriate documentation and patient care. Not best evidence of accuracy with their ability to rule out covered in this algorithm are socioeconomic issues false-positives and demonstrated validity with multiple and psychosocial factors that may be important in the compounding factors, including psychological factors, clinical decision-making process. In this complete evaluation will assist in complying with regu approach, the investigation of facet joint pain is con lations, providing appropriate care, and fulfilling an sidered as a prime investigation, ahead of disc provoca algorithmic approach. In the United States, commonly proach for chronic low back pain without disc hernia performed diagnostic blocks are often accomplished tion (8,2155). For confirmed disc herniation, radiculitis, with 2 separate local anesthetics in what is referred to or spinal stenosis, diagnostic approaches depend on as controlled comparative local anesthetic blocks with symptoms, signs, and radiologic evaluation. If a patient expe algorithmic approach for chronic low back pain without riences at least 75% relief with the ability to perform disc herniation is based on the best available evidence previously painful movements within a timeframe that on the epidemiology of various identifiable sources of is appropriate for the duration of the local anesthetic chronic low back pain. Facet joint pain, discogenic pain, used and the duration of relief with the second block and sacroiliac joint pain have been proven to be com relative to the first block is commensurate with the re mon causes of pain with proven diagnostic techniques spective local anesthetic employed in each block, then, (8,11,13,15,17,33,36-38,644,1250,1325,1469,1471,2155). However, based on patient If there is evidence of radiculitis, spinal stenosis, condition and regulations, the criterion standard of A comprehensive algorithm for the evaluation and management of chronic spinal pain. An algorithmic approach to diagnosis of chronic low back pain without disc herniation. In that case, only one negative disc is needed with tenderness over the sacroiliac joint (8,17,1461). Lumbar provocation discography is the the ability to perform previously painful movements last step in the diagnostic algorithm and is utilized only and also should be concordant based on the local anes when appropriate treatment can be performed if disc thetic injection with a bupivacaine injection outlasting abnormality is noted (8,2155). However, based on patient is to satisfy patients? impressions if the patient does not condition and regulations, the criterion standard of improve with any other modalities of treatments. Caudal and lumbar inter low back pain without disc herniation or spinal stenosis. Pro Even though, disc protrusion, herniation, and pro vocative lumbar discography is performed as the first lapse resulting in sciatica are seen in less than 5% of the test in only specific settings of suspected discogenic patients with low back pain (374,554,1559), many patients pain and availability of a definitive treatment is offered with post surgery syndrome, spinal stenosis, and radiculitis or solely for diagnostic purposes prior to fusion. Other without disc protrusion may respond to epidural injections wise, once facet joint pain, and if applicable sacroiliac (8-10,28,30,31,722,765,766,906,968,1037,1038,1759). Pa joint pain, is ruled out and the patient fails to respond tients non-responsive to epidural injections will require to at least 2 fluoroscopically directed epidural injec either mechanical disc decompression (21-24), percuta tions, discography may be pursued if determination of neous adhesiolysis (19), or implantation of a spinal cord the disc as the source of pain is crucial. Provocation dis lumbar transforaminal epidural injections in managing cography continues to be controversial with respect to radicular pain or disc herniation (28,30,31). In addition, diagnostic accuracy and its impact on surgical volume the evidence is fair for caudal, lumbar interlaminar, and (39). Lumbar discography has been refined substantially transforaminal epidural injections in managing spinal ste since its inception and its diagnostic accuracy is fair (39). The evidence for lumbar interlaminar to good for lumbar facet joint nerve blocks and good for epidural injections in post surgery syndrome is not avail lumbar radiofrequency neurotomy (12). The evidence assessment is based on contemporary the next modality of treatment is epidural injec practice in interventional pain management settings for tions. Epidural injections show variable evidence in all the procedures performed under fluoroscopy. The as Consequently, a patient without previous surgical sessment of the evidence from these guidelines and intervention with unilateral, single, or 2 level involve systematic reviews (28,30,31) is fair with caudal and ment may be treated with transforaminal, caudal, or interlaminar epidural injections and limited with trans interlaminar approaches. However, bilateral or involve foraminal epidural injections in managing axial or dis ment of multiple segments will lead to either interlami cogenic pain without disc herniation, radiculitis, facet nar or caudal epidural injections based on the upper or joint pain, or sacroiliac joint pain. In case of extensive stenosis the evidence for therapeutic sacroiliac joint inter or lack of response to caudal or interlaminar approaches, ventions is fair for cooled radiofrequency neurotomy, transforaminal epidural approach may be appropriate. Figure 10 illustrates therapeutic algorithmic man the assessment of evidence for intradiscal proce agement. In contrast, based on the re may be considered for mechanical disc decompression, Chronic Low Back Pain Somatic Pain Radicular Pain I. Post surgery Cooled radiofrequency thermoneurolysis Step 4: Spinal cord stimulation *Evidence is limited **Evidence available only for post surgery syndrome and spinal stenosis Fig. A suggested algorithm for therapeutic interventional techniques in management of chronic low back pain. Only recently, one randomized trial dural injections is good for radiculitis secondary to disc was conducted for nucleoplasty providing fair evidence. In contrast, cervical transforaminal epidural injec In patients with post-lumbar surgery syndrome tions have been associated with high risk and without after failure to respond to fluoroscopically directed evidence either for diagnostic or therapeutic purposes epidural injections, percutaneous adhesiolysis is con (934,1010,1023-1031,1646,1758). Based on the current literature, the approach should include the diagnostic interventions evidence is fair to good for percutaneous adhesiolysis with facet joint blocks, therapeutic epidural injections, in managing post lumbar surgery syndrome and spinal followed by discography. Thus, the facet joints are been tried without sufficient improvement in pain con entertained first in the algorithm in patients without trol. Multiple studies have cancer pain may be achieved with intrathecal infusion indicated the facet joint pain to be bilateral in 69% to systems (27). The 72% of cases and involving at least 3 joints in 50% to literature continues to be scant with no randomized trials 85% of patients (14,1345-1347,1857). This with 2 different local anesthetics, a positive diagnosis is represents an algorithmic approach for the investigation made. However, based on patient condition and regula of neck pain based on the best available evidence on the tions, the criterion standard of pain relief and either a S186 An algorithmic approach to diagnosis of chronic neck pain without disc herniation. Once facet joint pain is ruled out and the is the last step in the diagnostic algorithm and is utilized patient fails to respond to at least 2 fluoroscopically only when appropriate treatment can be offered if the directed epidural injections, discography may be pur disc abnormality is demonstrated. However, a rare but sued if the determination of the disc as the source of justifiable indication is to satisfy the patients? impres pain is crucial. However, to be valid, the provocation sions if the patient does not improve with any other discography must be performed utilizing criteria with modalities of treatment. Thus far, studies have demon concordant pain in one disc with at least 2 negative strated the effectiveness of epidural injections in the discs, with evoked intensity of pain of 7 of 10 or 70% of cervical region in discogenic pain (9,13,38,251,746,772, worst spontaneous pain. These modalities in managing spinal stenosis are less common in the cervical spine chronic intractable neck pain have not been evaluated. Ra diculitis may also result from cervical spinal stenosis, post surgery syndrome, and discogenic pain without 4. The current evidence indicates lack of Figure 13 illustrates the diagnostic algorithmic ap evidence for transforaminal epidural injections and proach for chronic thoracic pain without disc herniation high risk with good evidence for cervical interlaminar or radiculitis. The current literature algorithmic management of chronic neck pain, patients review shows that based on the controlled, compara testing positive for facet joint pain may undergo either tive local anesthetic blocks, thoracic facet joint pain therapeutic facet joint nerve blocks or radiofrequency has been shown to be present in approximately 40% of neurotomy based on patients? preferences, values, patients with mid-upper back pain with false-positive and physician expertise. Current evidence synthesis of rates of 42% with good evidence of accuracy (15,16). Thus, intraarticular facet joint litis or disc herniation or other demonstrable causes injections are not indicated in cervical facet joint pain. Post surgery or Step 3: *Spinal cord stimulation Surgical referral *Limited evidence **No evidence Fig. A suggested algorithm for therapeutic interventional techniques in the management of chronic neck pain. The current literature shows fair ful movements with a concordant response in relation evidence for the effectiveness of thoracic interlaminar to duration of local anesthetics, a positive diagnosis is epidural injections. However, based on patient condition and regula should include diagnostic interventions with facet joint tions, the amount of achieved relief and either a single blocks, epidural injections, and in rare circumstances, block or double block paradigm is changed. Once facet joint pain is ruled out and the patient with clinical questions, clinical findings, and findings of fails to respond to at least 2 fluoroscopically directed imaging.

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Various illumination sources erectile dysfunction from adderall buy cheap sildalis 120mg online, wavelengths of light erectile dysfunction over 80 order sildalis 120 mg overnight delivery, and dosing schedules have been used erectile dysfunction ulcerative colitis order 120mg sildalis overnight delivery. Photodynamic therapy is well-suited for large lesions erectile dysfunction for young men buy generic sildalis 120 mg on-line, multiple lesions, and poor-healing sites. There may be rarely observed adverse effects like erosions, ulceration, and hyperpigmentation hypopigmentation. Radiotherapy: X-ray or grenz-ray radiation therapy may be given for poor surgical candidates or patients with multiple lesions. In this case, excision of bladder cancer due to chronic arsenicosis can be curative. In advanced cases of these cancers and in cases of internal cancers, the treatment options are meager. Surgical intervention in mild-to-moderate keratotic papules or nodules has not been widely tried. Those lesions with sudden increase in size, cracks, and bleeding; and those of Bowen? Effectiveness of zinc in modulating perinatal effects of arsenic on the teratological effects in mice offspring. Alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmer arsenical keratosis patients. Blood concentrations of methionine, selenium, beta-carotene, and other micronutrients in a case-control study of arsenic-induced skin lesions in West Bengal, India. Randomized double-blind trial to evaluate the effectiveness of topical administration of propylene glycol in arsenical palmer keratosis. Effect of ethanol extract of leaves of Azadirachta indica on palmar arsenical keratosis: A single-blind trial. Protective effect of thymoquinone against arsenic-induced testicular toxicity in rats. International Journal of Medical, Pharmaceutical Science & Engineering, 8(2), 46-49. Folate and arsenic metabolism: A double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh. Chronic arsenicosis of cattle in West Bengal and its possible mitigation by sodium thosulfaye. Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. Randomized placebo-controlled trial of 2, 3-dimercaptosuccinic acid in therapy of chronic arsenicosis due to drinking arsenic-contaminated subsoil water. Serum beta-carotene level, arsenic methylation capability, and incidence of skin cancer. Randomized controlled trial to evaluate the effectiveness of topical use of salicylic acid for treatment of keratosis in arsenicosis patients. Successful treatment of multiple pre-malignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil. Diet, alcohol, smoking, serum beta-carotene, and vitamin A in male nonmelanocytic skin cancer patients and controls. Vitamin E levels in buccal cells of arsenicosis patients following vitamin E supplementation. Efficacy of spirulina extract plus zinc in patients of chronic arsenic poisoning: A randomized placebo-controlled study. Therapeutics & Clinical Risk Management, 4(5), 1085-1095 [34] Noor-E-Tabassum, (2006). Effect of water hyacinth root extract on arsenic level in different organs of arsenic-treated rat. Effect of ascorbic acid on reduced glutathione level in arsenic-loaded isolated liver tissues of rat. Successful treatment of palmoplantar arsenical keratosis with a combination of keratolytics and low-dose acitretin. A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh. Protective effects of selenium on oxidative damage and oxidative stress related gene expression in rat liver under chronic poisoning of arsenic. Proverb ounselling of people for public education and social movalization is C an important aspect in arsenic endemic area. We should have sufficient authentic information about arsenic and arsenicosis before starting counseling. There is a common practice that Government denies or suppresses the information of arsenic contamination when it is first discovered (Ravenscroft et al. It is due to reliability of information; chance to develop penic among. However, this type of ignorance does not protect people from arsenic contamination. A study conducted in Bangladesh after 5-6 years of detection showed that more than 60% of people have no idea about arsenic. Actually it is present everywhere and does not produce any health problem until the concentration is high. But it is difficult in endemic area of highly populated, particularly in Bangladesh and West Bengal. Continue to educate children about the serious health risks of consuming arsenic contaminated water. Repeatation is information about arsenic and its consequent health effects are important. Advice the patient and other family members not to drink arsenic contaminated water. Arsenic contaminated water should not be used to drink by cow, chiken or other household animals. The level of arsenic in hand pumped tube wells was estimated by national testing campaign in Bangladesh. Motivation of people is necessary for periodic check up of both red marked and green marked hand pumped and motor driven tube wells for the level of arsenic with the help of local government. Eating or sleeping with someone who has arsenicosis, a healthy person could be infected. Supplementation of vitamin A, C and E tablets may be taken by the patient continuously daily for three months followed by drug holiday of one month. The amount of vitamins depends upon the age of the patient and severity of non-malignant symptoms. People in arsenic endemic area are willing to walk a long distance to avoid exposure if the source for arsenic-free water is a hand pump tube well. If the source for arsenic-free water is surface water, however, people are less likely to walk a long distance to take avoidance measures (Aziz et al. Persons with poor health may also find it inconvenient to travel a long distance to collect arsenic safe drinking water. Knowledge of Arsenic in Drinking-water: Risks and avoidance in Matlab, Bangladesh. He joined as Associate Professor at the Institute of Postgraduate Medicine and Research, Dhaka in 1993 and was promoted to Professor in Bangabandhu Sheikh Mujib Medical University in 2001. He was the editor of Bangladesh Medical Research Council Bulletin, Bangladesh Journal of Physiology and Pharmacology, Teachers? His keen interest is in the field of both asynchronous and synchronous virtual pharmacology. In asynchronous teaching, a student can use the teaching contents from a website at anytime, from anywhere and several times. In the synchronous teacher, he is trying to arrange live lectures for students of Pharmacology at under and post-graduate level from home and abroad.

References:

  • https://www.hematologyandoncology.net/files/2019/07/ho0719Sup11-1.pdf
  • http://stupidcancer.org/wp-content/uploads/2018/12/ccwp.pdf
  • https://www.fairfaxcounty.gov/environment/sites/environment/files/assets/documents/pdf/sustainability-initiatives-report-fy-2017.pdf